1.What is Parkinson’s disease?
Parkinson’s disease (PD), also known as tremor paralysis, is one of the most common neurodegenerative diseases. Patients over 50 years old account for more than 90% of the total number of patients. The etiology and pathogenesis of PD are not clear. At present, the research results believe that the disease is related to comprehensive factors such as age, exposure to environmental toxins and genetic susceptibility.
The symptoms of Parkinson’s disease are divided into motor symptoms and non motor symptoms. There are three main motor symptoms, namely static tremor, increased muscle tone and bradykinesia, which can be summarized as three words – “shaking, stiffness and slowness”. Shaking refers to the involuntary tremor of hands, arms, legs, face and jaw. Generally speaking, it refers to hand shaking, foot shaking and mouth shaking. This tremor is obvious when the body is quiet and static, aggravated when the mood is tense, reduced during activity and disappeared during sleep. Stiffness refers to that the muscles become tight, the facial expression decreases, the limbs feel stiff, sore, heavy and inflexible when they move, they can’t stand up freely after sitting down, they can’t turn over on their own when lying in bed, and they are slow and difficult when turning and starting. Slow refers to the slow movement. In daily life, the actions such as brushing teeth and washing face, dressing and taking off shoes, tying shoelaces and buttons become slower. The more you write, the smaller you write, the less you can walk, and the smaller you walk, the faster you walk; The non motor symptoms of Parkinson’s disease include anosmia, fatigue, anxiety and depression, insomnia, constipation, salivation, mental symptoms, abnormal sweating, dementia and so on, which seriously affect the quality of life of patients.
2.Does hand shaking cause Parkinson’s disease?
Hand shaking is a very common symptom. Palpitation and hand shaking will occur when there is simple psychological and emotional tension. In addition, hyperthyroidism and the use of hormone drugs can also cause hand shaking symptoms. In terms of Neurology, the most common disease related to hand shaking is idiopathic tremor, which is also one of the common reasons for visiting neurology outpatients. So what’s the difference between this hand shaking and Parkinson’s disease?
First, in most cases, idiopathic tremor only has the symptoms of hand or head shaking, not accompanied by the symptoms of stiff limbs, inflexibility, less movement and expression as described above.
Second, the shaking of idiopathic tremor can involve the head and hands, but it mostly occurs when maintaining a certain posture. For example, when the head is sitting upright without leaning, the head can shake head or nod, and disappear when lying flat on the pillow. For another example, many patients shake their hands when holding cups or holding vegetables with chopsticks, and there is basically no obvious static tremor when they are quiet. The tremor of Parkinson’s disease is the most specific static tremor, which is manifested in complete relaxation, such as a slightly rotating tremor when lying flat with both hands on the bed, also known as “rubbing pills”.
Third, idiopathic tremor disappeared or significantly reduced in some patients after drinking, but drinking is not recommended because the disadvantages outweigh the advantages. Fourth, idiopathic tremor usually has a family genetic history. The disease often progresses slowly. The symptoms continue but do not increase significantly. It only increases slightly in old age. Generally, it does not affect daily life. When the symptoms are mild, there is no need for drug treatment. However, the motor symptoms of Parkinson’s disease progress rapidly, and once diagnosed, it is recommended to start treatment as soon as possible.
3.Can Parkinson’s disease be ruled out if medoba and other drugs are ineffective?
In the early stage of Parkinson’s disease, patients may only have tremor and slow movement, which is easy to be confused with idiopathic tremor. However, in the early stage of Parkinson’s disease, the effect of dopamine drugs or dopamine receptor agonists is more significant. Therefore, in order to identify whether the tremor caused by Parkinson’s disease, doctors often give patients some dopamine drugs first, which is an important basis for the diagnosis of Parkinson’s disease. If the drug can improve the motor symptoms of Parkinson’s disease, it indicates that the patient may suffer from Parkinson’s disease rather than primary tremor; If it is ineffective, the diagnosis of primary Parkinson’s disease can be basically ruled out, while secondary Parkinson’s disease such as Parkinson’s syndrome is not sensitive to Madopa treatment. At present, the medical diagnosis of Parkinson’s disease is mainly based on whether the patient has typical symptoms such as tremor, bradykinesia and muscle stiffness, and whether dopamine drugs are effective. Drug treatment generally takes several weeks to take effect. At present, there is no blood index or imaging standard to directly diagnose Parkinson’s disease.
4.How to treat Parkinson’s disease?
Parkinson’s disease is a chronic disease. Most patients have a course of more than ten years and need lifelong treatment. Due to the slow aggravation of symptoms, there is no complete cure at present. Therefore, the goal of treatment is to improve the quality of life of patients and maintain the functional independence of patients for a long time as possible. To this end, treatment methods also need to be considered from multiple perspectives, including drugs, surgery, functional rehabilitation, psychology and nutrition, which often require the joint participation of multiple disciplines.
At present, drug therapy is the main treatment for patients with Parkinson’s disease. Due to the decrease of dopamine producing nerve cells in patients with Parkinson’s disease, the amount of dopamine in the brain is insufficient. Dopamine is the “stepping stone” for communication between nerve cells. If dopamine is insufficient, the signal transmission between nerve cells will be greatly affected. Therefore, the method of drug treatment is to increase the effect of dopamine through various ways.
5.How to prevent Parkinson’s disease
In life, pay attention to stay away from pesticides and herbicides, away from decoration pollution, and avoid exposure to substances toxic to human body, such as carbon monoxide, manganese, mercury, etc. Some drugs may cause tremor. The elderly should use them as little as possible and avoid taking drugs that may induce Parkinson’s like symptoms such as perphenazine, reserpine and chlorpromazine. Control basic diseases, control blood pressure, blood glucose and blood lipid, actively prevent cerebral thrombosis, and strengthen physical exercise and mental activities. In case of hand tremor, foot tremor, slow walking, slow activity, physical stiffness and other suspected manifestations of Parkinson’s disease, early medical treatment, early diagnosis, early treatment and early benefit should be obtained.