What causes Alzheimer’s disease?The etiology of senile dementia is not very clear, but it is known that there are many causes of senile dementia.
1,Brain degenerative diseases: there are many kinds of dementia caused by brain degenerative diseases. The most common is Alzheimer’s disease dementia, which is also called Alzheimer’s disease. Its onset is slow, and it is progressive dementia. In addition, there are Pick’s disease, tington chorea dementia, progressive supranuclear palsy, Parkinson’s disease dementia and so on. These dementia in the back are relatively rare.
2,Cerebrovascular disease: the most common is multiple cerebral infarction dementia, which is caused by a series of multiple mild ischemic attacks and multiple accumulation of cerebral parenchymal infarction. In addition, there are subcortical vascular dementia and acute attack cerebrovascular dementia, which can rapidly develop into dementia after stroke caused by a series of cerebral hemorrhage and cerebral embolism, and a few can also be caused by a large area of cerebral infarction. In short, cerebrovascular disease is also a common cause of Alzheimer’s disease.
3,Genetic factors: many studies at home and abroad have proved that the offspring of Alzheimer’s patients have more opportunities to suffer from the disease. However, its genetic mode is still unclear. Some people think it is inherited by dominant genes; Others think it is inherited by recessive gene; Others believe that it is polygenic autosomal recessive inheritance, and the genetic function can be restricted by the mutation of environmental factors and genetic factors, so as to interrupt its genetic function. There are also some studies that senile dementia is a non genetic disease, such as vascular dementia, which is not directly related to heredity.
4,Endocrine diseases: such as hypothyroidism and parathyroidism may cause dementia.
5,Nutritional and metabolic disorders: brain tissue and its function are damaged due to nutritional and metabolic disorders, resulting in dementia. For example, encephalopathy caused by various organs, such as renal encephalopathy, is cerebral ischemia and hypoxia caused by chronic renal failure and uremia, which can lead to dementia; Other diseases such as hepatic encephalopathy and pulmonary encephalopathy can lead to dementia. Severe nutritional deficiency, such as vitamin B1, B12, niacin and folate deficiency, can lead to dementia. Diabetes and hyperlipidemia can cause atherosclerosis in the large and middle arteries. Thickening of the basement membrane of small blood vessels and microvessels can cause cerebral infarction and cerebral hemorrhage, leading to vascular dementia.
6,Tumor: metabolic disorder caused by malignant tumor can lead to dementia, and brain tumor can also directly damage brain tissue to lead to dementia.
7,Drug and other substance poisoning: Alzheimer’s disease caused by alcoholism and chronic semen poisoning is not uncommon, but it has not been recognized by people. Long term exposure to aluminum, mercury, gold, silver, arsenic and lead with poor protection can lead to dementia after chronic poisoning. Carbon monoxide poisoning is also one of the common causes of acute dementia.
8,AIDS: AIDS is one of the causes of Alzheimer’s disease. Alzheimer’s disease is known to be present in the elderly at the early stage of AIDS, and it has been proved that the central nervous system can directly infect human immunodeficiency virus (HIV).
9,Syphilis: Treponema pallidum can invade the brain, produce mental and neurological symptoms, and finally lead to paralysis and increasing mental retardation and personality changes, the so-called paralytic dementia.
10,Others: Alzheimer’s disease can be caused by brain trauma, persistent seizures of epilepsy and normal pressure hydrocephalus. In addition, the elderly’s long-term emotional depression, living alone, widowhood, illiteracy, low language level, lack of physical and mental exercise can also accelerate the process of brain aging and induce Alzheimer’s disease.