What is Aspirin？Aspirin [2 – (acetoxy) benzoic acid, also known as acetylsalicylic acid, acetylsalicylic acid] is a white crystalline or crystalline powder, odorless or slightly acetic acid odor, slightly soluble in water, easily soluble in ethanol, soluble in ether and chloroform, and the aqueous solution is acidic. This product is a derivative of salicylic acid. After nearly 100 years of clinical application, it has been proved that it has a good effect on alleviating mild or moderate pain, such as toothache, headache, neuralgia, muscle ache and dysmenorrhea. It is also used for antipyretic of febrile diseases such as cold and influenza, and for the treatment of rheumatic pain. In recent years, aspirin has been found to inhibit platelet aggregation and prevent thrombosis. It is clinically used to prevent transient ischemic attack, myocardial infarction, artificial heart valve, venous fistula or other post-operative thrombosis.
R & D history
As early as 1853, Gerhardt synthesized acetylsalicylic acid (acetylated salicylic acid) from salicylic acid and acetic anhydride, but it failed to attract people’s attention. In 1897, German chemist Felix Hoffman synthesized it again and treated rheumatoid arthritis for his father with excellent curative effect. In 1897, Bayer, Germany, synthesized the main substance of aspirin for the first time.
Aspirin was listed in 1898. It was found that it also has the effect of anti platelet aggregation, so it has aroused great interest again. Aspirin and other salicylic acid derivatives are melt esterified with hydroxyl containing polymers such as polyvinyl alcohol and cellulose acetate to make them high molecular. The anti-inflammatory, antipyretic and analgesic properties of the product are longer than those of free aspirin.
By 1899, Bayer sold this drug to the world with aspirin as its trademark.
By 2015, aspirin has been used for 100 years and has become one of the three classic drugs in the history of medicine. So far, it is still the most widely used antipyretic, analgesic and anti-inflammatory drugs in the world. It is also a standard preparation for comparing and evaluating other drugs. It has antithrombotic effect in vivo. It can inhibit the release reaction of platelets and inhibit the aggregation of platelets, which is related to the reduction of TXA2 production. Clinically, it is used to prevent the attack of cardiovascular and cerebrovascular diseases.
Aspirin can inhibit platelet aggregation, so the indications of aspirin enteric coated tablets are as follows:
1,Reduce the risk of suspected patients with acute myocardial infarction
2,Prevention of recurrence of myocardial infarction
3,Secondary prevention of stroke
4,Reduce the risk of transient ischemic attack (TIA) and its secondary stroke
5,Reduce the risk of patients with stable and unstable angina pectoris
6,After arterial surgery or intervention, such as percutaneous transluminal coronary angioplasty (PTCA), coronary artery bypass (CABG), carotid endarterectomy, and arteriovenous shunt
7,Prevention of deep venous thrombosis and pulmonary embolism after major surgery
8,reduce the risk of myocardial infarction by reducing cardiovascular risk factors (family history of coronary heart disease, diabetes, dyslipidemia, hypertension, obesity, smoking history, and age over 50).
Usage 1: antipyretic analgesic, used for fever, pain and rheumatoid arthritis.
Usage 2: it is the earliest, most widely used and most common antipyretic analgesic and anti rheumatic drug. It has many pharmacological effects, such as antipyretic, analgesic, anti-inflammatory, anti rheumatism and anti platelet aggregation. It has a rapid and definite effect. Over dose is easy to diagnose and deal with, and allergic reactions rarely occur. Commonly used in cold fever, headache, neuralgia, arthralgia, muscle pain, rheumatic fever, acute internal wet arthritis, rheumatoid arthritis and toothache. Acetylsalicylic acid is also an intermediate of other drugs.