With the widespread use of drugs and the widespread existence of drug abuse, the incidence of drug-induced renal damage is significantly increased. The harm of 4 kinds of drugs such as antipyretic analgesic, antihypertensive drug to kidney is very big. Life will inevitably encounter small ailments, uncomfortable when we often use medicine. However, the prevalence of drug abuse in recent years has significantly increased the incidence of drug-induced renal damage. The following four drugs are very harmful to the kidney.
Antipyretics and analgesics are important drugs that harm the kidneys. All kinds of cold medicines, such as anemin, phenolamine camin tablets, acetaminophen, compound pseudoephedrine hydrochloride sustained-release capsules; Pain relievers such as ibuprofen, indometacin, naproxen, diclofenac sodium preparations, compound acetaminophen tablets, and celecoxib can cause kidney damage.
Blood pressure medication
Commonly used antihypertensive agents such as diuretics, angiotensin converting enzyme inhibitors and angiotensin receptor antagonists may cause renal damage. All three types of drugs may cause acute allergic interstitial nephritis, and the latter two may also cause acute renal failure by reducing renal perfusion. For patients with moderate or severe renal function impairment, the latter two may sometimes cause short-term renal function deterioration, which is more likely to occur in patients with bilateral renal artery stenosis, combined use of diuretics, non-steroidal anti-inflammatory drugs, cardiac insufficiency and dehydration.
Contrast agent can not only cause renal vasoconstriction and kidney injury, but also stimulate the production of reactive oxygen species and directly damage renal tubular epithelial cells. Therefore, a comprehensive risk assessment should be made before the use of contrast agents. For patients with chronic renal insufficiency, diabetes, hypertension and advanced age, isotonic, low viscosity and non-ionic contrast agents are recommended, and the dose should be reduced as far as possible to avoid repeated use in a short term.
Aminoglycoside drugs (neomycin or gentamicin, etc.) are the most common cause of drug-induced renal damage due to their high renal toxicity. The clinical manifestations of renal injury are hematuria, proteinuria, and tubular urine, and in severe cases oliguria, anuria, or acute renal failure. Two drugs, penicillin or cephalosporin, can cause allergic interstitial nephritis, which is characterized by systemic symptoms such as rash, arthralgia and fever. Other drugs such as quinolones (ciprofloxacin and norfloxacin, etc.), erythromycin, lincomycin, vancomycin, norvancomycin and antiviral drugs (acyclovir, lamivudine and interferon, etc.) can also cause kidney damage.