Clopidogrel has little side effects and can replace aspirin?

alopah Date:2021-09-13 14:34:43
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Some people will think that the more expensive the medicine, the better, but it’s not that the more expensive the medicine, the better! Plavix costs 15 yuan and aspirin 50 cents. Many people think that clopidogrel is more expensive than aspirin and must be better than aspirin, so they replace aspirin with clopidogrel by themselves. In fact, it’s not what you think. Clopidogrel can’t replace aspirin. The guide suggests that clopidogrel can replace aspirin only when you can’t tolerate aspirin.


Under what circumstances can aspirin not be used?

1,Aspirin allergy


People who are allergic to aspirin or other salicylates must not take aspirin.


2,History of asthma

Patients with a history of bronchial asthma may have acute upper and lower respiratory tract reactions if taking aspirin, which can lead to bronchial obstruction and respiratory failure in severe cases. In case of asthma attack, the greater the dose, the more serious the reaction.


3,Gastric ulcer, duodenal ulcer, acute gastrointestinal bleeding

The most common side effect of aspirin is gastrointestinal bleeding. People with definite gastrointestinal bleeding cannot use aspirin. People with gastric ulcer or duodenal ulcer should try not to use aspirin.


4,Definite active organ bleeding

Aspirin should not be used for any organ active bleeding.


5,Severe aspirin resistance


After taking aspirin for a long time, thrombosis or embolism will still occur. Laboratory tests show that the antiplatelet ability is low. In other words, the effect of taking aspirin is not good.




What drug is clopidogrel?

Aspirin is a big brother, more than 100 years old this year; Clopidogrel is a little brother, 20 years old this year; These two brothers are anti platelet aggregation drugs, which can prevent thrombosis.


Clopidogrel, like aspirin, is a drug for the treatment of ischemic cardiovascular and cerebrovascular diseases, such as coronary heart disease, cerebral infarction, post stenting, acute coronary syndrome and so on.


However, the mechanism of action of the two drugs is different. In short, aspirin is antiplatelet through one method and clopidogrel is antiplatelet through another method. All roads lead to Rome.


What disease is clopidogrel most commonly used for?

For patients with acute myocardial infarction or friends with cardiac stents, this drug is no stranger. Because all stents or acute myocardial infarction need to take aspirin + clopidogrel at the same time.


This is called double insurance, that is, we are afraid that the role of aspirin in preventing vascular blockage is not safe enough, and then we can prevent vascular blockage in another way. Our professional term is double antiplatelet.


Adverse reactions of clopidogrel:

Common: angioedema, epistaxis, gastrointestinal bleeding, bruise, abdominal discomfort, diarrhea, dyspepsia, etc.


Uncommon: thrombocytopenia, headache, dizziness, eye bleeding, gastric ulcer, constipation, rash, hematuria, etc.


Clopidogrel is forbidden: it is forbidden for patients with severe liver damage, active peptic ulcer, intracranial hemorrhage and allergy to clopidogrel. Therefore, it does not mean that clopidogrel has small side effects. More importantly, aspirin and clopidogrel should be added unless double insurance is required.


How to choose aspirin and clopidogrel:

When only one antiplatelet drug is needed, we first choose aspirin in clinic, because aspirin has rich experience in medication and more sufficient evidence of antiplatelet and thrombosis prevention, we do not recommend replacing aspirin with clopidogrel. Aspirin’s antiplatelet status has not been shaken for the time being.


Therefore, clopidogrel should be considered only if aspirin cannot be tolerated.

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