Ibuprofen is often used. You should know if you can’t use it. Ibuprofen is not a panacea. In some cases, taking it can be dangerous. This has been summarized recently.
Have heart disease
Although taking low-dose aspirin can help prevent heart attack, there is a correlation between other painkillers (including ibuprofen) in the non steroidal anti-inflammatory drugs (NSAIDs) family and the increased risk of heart attack or stroke. According to the research results published in the British Medical Journal by researchers from the University of Montreal, Canada, the risk of heart attack increased by 20% ~ 50% in people taking NSAIDs every day for a week or more, and the increased risk associated with ibuprofen can be as high as 75%. In the first month of taking nonsteroidal anti-inflammatory drugs, and people taking high doses are at greatest risk.
Anticoagulants (such as warfarin) and antiplatelet drugs (such as clopidogrel) can prevent thrombosis. The former is usually used in patients with high-risk stroke (such as patients with atrial fibrillation or artificial heart valve replacement), or patients with pulmonary embolism; The latter is usually used for patients who have had a heart attack or stroke, which is a way to prevent their heart disease from happening again. The problem is that the combination of these drugs with ibuprofen increases the risk of hemorrhagic complications. At this point, celecoxib can be considered, which is unlikely to cause bleeding.
Have gastrointestinal problems
NSAIDs not only stimulate the vascular intima of stomach and intestine, but also reduce the blood flow in this area and weaken its own repair ability. Therefore, if you already have digestive problems (such as inflammatory bowel disease, IBD), you should be careful when taking these drugs. They are ineffective for IBD related pain. For example, if you have a headache, acetaminophen (acetaminophen) is a better choice. If it is a woman’s menstrual pain, taking contraceptives can also help.
NSAIDs can cause harm to the fetus, increase the risk of abortion in early pregnancy and increase the risk of fetal heart defects in late pregnancy. The research results published in human reproduction by researchers from the University of Edinburgh in the UK show that there is a correlation between women taking ibuprofen in the early pregnancy and subsequent fetal ovarian egg dysplasia, which may affect their daughter’s future fertility. Pregnant women should not take ibuprofen during delivery, because it may lead to long-term bleeding.
Have urinary tract infection
In 2014, researchers from Washington University School of medicine in St. Louis reported that NSAIDs may be useful in the treatment of urinary tract infections. In addition to relieving pain, it can also reduce recurrence and help avoid antibiotic resistance. However, there is conflicting evidence in the literature on the efficacy of ibuprofen, and it depends on the antibiotics compared with it. In addition, the research results published in the Journal of the public library of Science – medicine by medical scientists at the University of Oslo in Norway show that women taking ibuprofen to treat urinary tract infections take an average of three days more to recover than women taking antibiotics, and their risk of complications is slightly higher.
Patients with arthritis take ibuprofen and other non steroidal anti-inflammatory drugs for a long time to treat the pain caused by arthritis. However, due to its negative effects on the gastrointestinal tract and cardiovascular system, some patients (especially those with a history of stomach or heart problems) should think twice before taking ibuprofen. A study published in the European Heart Journal by medical scientists at the University of Zurich in Switzerland compared the effects of different types of NSAIDs (ibuprofen, naproxen and celecoxib) on blood pressure in patients with osteoarthritis and rheumatoid arthritis. The results showed that all three drugs were associated with an increased risk of hypertension, and ibuprofen had the greatest impact. 23.2% of patients taking this drug developed hypertension, while naproxen and celecoxib were 19% and 10.3% respectively. More importantly, for patients with rheumatoid arthritis, taking NSAIDs is not enough to control inflammation and prevent further joint injury.
Alcohol and NSAIDs can stimulate the stomach. When the two are combined, the stimulation to the stomach is greater, and the risk of gastric ulcer and liver injury is increased.
Get ready for hard exercise
Some endurance athletes take ibuprofen before long-distance running to prevent muscle pain. This is not only a waste of time and money, but also harmful. Because ibuprofen has analgesic effect, you may not know whether you are overworked. In addition, taking ibuprofen during high-intensity training can aggravate exercise-induced kidney damage. According to the research results published in the British Medical Journal emergency medicine by medical experts from Stanford University in the United States, athletes taking 1200 mg ibuprofen for super Marathon (about 80 km) will be 18% more likely to suffer from acute kidney injury than athletes taking placebo.
This is because high-intensity exercise will impose a heavy burden on the kidney by attracting blood to the muscles for a long time. Taking ibuprofen (which can reduce the secretion of prostaglandins) will make the blood flow out of the kidney, which will cause a double blow to the kidney. Sometimes ibuprofen doesn’t help at all.
Sports medicine experts at the Federal University of Rio Grande do Sul in Brazil require athletes engaged in endurance events to take either ibuprofen or placebo. The results show that there is no difference between the two methods. One possible reason is that the effect of the drug on the heart may impair oxygen uptake and offset its pain relief benefits.
Ibuprofen and other NSAIDs inhibit inflammation by inhibiting an enzyme that reduces the production of a substance called prostaglandins, which helps heal. The problem is that intervention with prostaglandins may aggravate asthma. This is why ibuprofen’s drug instructions remind asthmatic patients to take it carefully. Asthma patients who are obviously sensitive to non steroidal anti-inflammatory drugs (such as ibuprofen) may have life-threatening bronchospasm.