Lactulose Oral Solution, trade name Dumic, Dumic. 1 Chronic functional constipation. 2 Adjuvant treatment of endotoxemia and hyperammonemic hepatic coma associated with impaired liver function. 3 Reduces blood urea nitrogen and creatinine levels and can be used for azotemia and uremia from various causes. This drug is classified under the drug categories of neurology, constipation, other gastrointestinal disorders, uremia, and other urological disorders.
Abdominal distention may occur during the first few days of treatment and usually disappears with continued treatment. When the dose is higher than the recommended therapeutic dose, abdominal pain and diarrhea may occur, at which point the dose should be reduced. Patients may develop electrolyte disturbances due to diarrhea if high doses are administered over a long period of time.
Lactulose Oral Solution Contraindications
2, Intestinal obstruction, acute abdominal pain and concomitant use with other laxatives.
3, Hypersensitivity to lactulose and its components.
Precautions to be taken when taking Lactulose Oral Solution
1, If constipation does not improve or recurs after two or three days of treatment, consult a doctor.
2, If this product is used in patients with lactase deficiency, the amount of lactose in this product should be noted.
3 , This product does not cause any problems for diabetic patients at constipation treatment doses. It should be used with caution in diabetic patients at higher doses for the treatment of hepatic coma or pre-coma.
4, This product has no effect on driving and mechanical handling at therapeutic doses.
5, If crystals precipitate during storage, dissolve in warm water and take. Keep out of the reach of children.
6, Elderly and infirm patients who have been taking the drug for more than six months should have their serum protein measured promptly.
Dosage and Administration of Lactulose Oral Solution
Note: The same drug may have different usage or dosage due to different package sizes. This article is for reference only. If you are not sure, please refer to the instructions that came with the drug or ask your doctor.
1,Hepatic encephalopathy: pre-cerebral coma and hepatic coma Treatment dose Starting dose: Oral solution: 30-50ml, 3 times daily. Maintenance dose: according to individual condition, care should be taken to avoid diarrhea. 2. Constipation: constipation treatment dose can be adjusted according to individual response, the following table can be used for reference. If no effect is seen within 48 hours, the dose can be increased; if diarrhea occurs, the dose should be reduced. Starting dose Maintenance dose (initial 3 days of treatment) Oral solution Oral solution (ml/day) (ml/day) Adult severe cases 30~45 15~25 Moderate cases 15~30 10~15 Mild cases 15 10 Children 7~14 years old 15 10 1~6 years old 5~10 5~10 Infants 5 5 It is better to take the medicine regularly. For example, take it once a day, after breakfast. Or divide the daily dose into two doses, one in the morning and one in the evening.
Lactulose Oral Solution Pharmacological Action
Lactulose is a synthetic non-absorbable disaccharide. It is not absorbed in the intestinal tract and can be decomposed into lactic acid and acetic acid by colonic bacteria to lower the intestinal pH below 6, thus blocking the absorption of ammonia, reducing the accumulation and absorption of endotoxin, restoring the patient’s blood ammonia to normal, and turning from coma to wakefulness. Lactulose also has the osmotic activity of disaccharide, which can retain water and electrolytes in the intestinal lumen and produce hypertonic effect, so it is also an osmotic laxative, and can be used to treat chronic functional constipation because it is not irritating to the intestine. Lactulose is a synthetic non-absorbable disaccharide. It is not absorbed in the intestine and can be decomposed by colonic bacteria into lactic acid and acetic acid, which can lower the intestinal pH to below 6, thus blocking the absorption of ammonia, reducing the accumulation and absorption of endotoxin, restoring the patient’s blood ammonia to normal and turning from coma to wakefulness. Lactulose also has the osmotic activity of disaccharide, which can make water and electrolytes retained in the intestinal lumen and produce hypertonic effect, so it is also an osmotic laxative, and can be used for the treatment of chronic functional constipation because it is not irritating to the intestinal tract.