Recombinant Human Interferon  α 2B injection | Encyclopedia of drugs


alopah Date:2021-09-15 14:42:55 From:alopah.com
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Common name: recombinant human interferon α 2B injection, trade name: anfuron, component: recombinant human interferon α 2B. Hydroxyethyl starch, without preservatives and blood extracts.

 

Pharmacology and Toxicology

pharmacology:

Recombinant Human Interferon  α 2B injection is the use of interferon carrying human leukocytes α 2b gene plasmid was produced by recombinant Pseudomonas. It has broad-spectrum anti-virus, anti-tumor, inhibiting cell proliferation and improving immune function.

 

Interferon binds to cell surface receptors, induces cells to produce a variety of antiviral proteins and inhibits virus reproduction in cells; Interferon can directly inhibit tumor cells, regulate host anti-tumor immune response, and change the relationship between host and tumor cells by inhibiting and decomposing factors required for tumor cell growth; Interferon improves immune function, including enhancing the phagocytosis of macrophages, enhancing the cytotoxicity of lymphocytes to target cells and the function of natural killer cells.

 

Toxicology:

Acute toxicity test: mice were injected intraperitoneally and intravenously with doses of 150 million international units per kilogram and 150 million international units per kilogram respectively, 105 and 104 times that of human treatment. There were no acute poisoning symptoms and no animal death.

 

Long term toxicity test: rats were injected intramuscularly with doses of 15 million international units per kilogram, 1.5 million international units per kilogram and 150000 international units per kilogram, five times a week for 6 months. There were no abnormalities in general condition, weight and behavior of rats. The above test was repeated in rabbits, and no toxic reaction was found in three months. The pathological examination of internal organs of rabbits did not find the changes caused by the toxicity of this product.

 

Pharmacokinetics

By intramuscular or subcutaneous injection, the peak time of blood drug concentration is 3.5 ~ 8 hours, and the elimination half-life is 4 ~ 12 hours. Renal catabolism is the main elimination pathway of interferon, and the elimination of bile secretion and liver metabolism is an important pathway. The absorption of intramuscular or subcutaneous injection was more than 80%.

 

Recombinant Human Interferon α 2B injection

 

indication

For the treatment of acute and chronic viral hepatitis (B, C, etc.), condyloma acuminatum, hairy cell leukemia, chronic myelogenous leukemia, lymphoma, AIDS associated Carbo Zis’s sarcoma, malignant melanoma and other diseases.

 

usage and dosage

This product can be injected intramuscularly, subcutaneously and intralesional.

 

1,Chronic hepatitis B: the recommended dose is 3-5 million international units (IU) each time, once a day or every other day, and 3-6 months is a course of treatment. The doctor can adjust the dose according to the specific situation of the patient.

 

2,Chronic hepatitis C: the recommended dose is 3-5 million international units (IU) each time, once a day or every other day, and 3-6 months is a course of treatment. The doctor can adjust the dose according to the specific situation of the patient.

 

3,Condyloma acuminatum: the recommended dose is 1-3 million international units (IU) each time. It is injected three times every other day every week. A course of treatment is 1-2 months.

 

4,Hairy cell leukemia: the recommended dose is 3 million international units each time, injected three times every other day every week. The doctor can adjust the dose according to the specific situation of the patient. Usually after 1-2 months of treatment, it shows curative effect, and then intermittent treatment can be carried out to make the condition alleviate for a long time.

 

5,Chronic myeloid leukemia: the recommended dose is 3-9 million international units per day for three months. The doctor can adjust the dose according to the specific situation of the patient. Maintenance treatment can be carried out after hemogram remission. It can be injected every other day. Cytogenetic indexes can be relieved after 9-10 months.

 

6,Lymphoma (vesicular): the recommended dose is 3 million international units, injected three times every other day every week. According to the tolerance of different patients, the dose shall be increased to the maximum tolerance (9-18 million international units) week by week as appropriate. It shall be injected three times every other day every week for 8-12 weeks as a course of treatment. If there is no aggravation or serious intolerance, this dose should be continued for at least 12 months. Doctors can adjust the dose according to the specific situation of patients, and cooperate with light chemotherapy to improve the curative effect.

 

7, AIDS related Carbo Zis’s sarcoma: recommended dose is daily injection of 18 million international units, if possible, the dose will gradually increase to 36 million international units. If there is no exacerbation or severe intolerance, we should continue to maintain this therapy. When the reaction was stable, the dose was changed to 18 million international units each time and injected three times every other day every week.

 

8,Malignant melanoma: the recommended dose is – 18 million international units each time, injected three times every other day until the curative effect appears, and then continued treatment. 18 million international units are injected each time, injected three times every other day. The doctor can adjust the dose according to the specific situation of the patient. 1. After surgical resection of stage II malignant melanoma, the use of this product for adjuvant treatment can reduce the recurrence rate.

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