As summer temperatures rise, weaker people such as young children and the elderly, especially those living alone, should be especially vigilant about heatstroke. In addition to high ambient temperature or humidity, fever, excessive obesity and hyperthyroidism, certain medications may also be causative factors. Drug-induced heatstroke is easily overlooked, and patients are found in a coma, which is very dangerous. Among the commonly used drugs, there are six main types of drugs that can cause heatstroke in humans.
1. Diuretics class of antihypertensive drugs. The common ones are thiazides, such as hydrochlorothiazide. Due to the high temperature in summer, the human body vasodilatation, after taking diuretic class antihypertensive drugs, will lead to insufficient effective circulating blood volume, reduce the amount of blood discharged from the heart, reduce sweating, cause dehydration and electrolyte imbalance, thus causing fatigue, lethargy, loss of appetite, panic and other symptoms of heat stroke.
Caution: After using the drug, hydration should be provided as needed.
2. Cold medicine containing pseudoephedrine. The effect of pseudoephedrine is mainly to contract the blood vessels of the upper respiratory tract, and also has a certain contraction effect on the blood vessels of the whole body, which will make the body sweat less, which is not conducive to heat dissipation on the surface of the body, thus causing heat stroke.
Caution: When taking such drugs, attention should be paid to avoid physical work in a hot environment.
3. Antipyretic and analgesic drugs. The common ones include ibuprofen, acetaminophen and so on. These drugs, while relieving heat and pain, also cause sweating, resulting in loss of potassium in the body, weakness in the limbs, and in severe cases, heat stroke due to dehydration.
Caution: Drink more water and eat more potassium-rich foods such as kiwi, bananas and bean products after taking such drugs. Generally speaking, antipyretic drugs should be taken up to four times a day, and if symptoms are not relieved you should seek medical attention as soon as possible.
4. Anticholinergics. Mainly M-choline receptor blockers, such as atropine, belladonna and other antispasmodic drugs, are commonly used to treat stomach pain caused by stomach cramps. These drugs prevent acetylcholine from binding to the receptors and cannot play a role in promoting glandular (including sweat gland) secretion, so anticholinergics can inhibit sweating, reduce heat release, and disrupt thermoregulation, which can directly lead to hyperthermia.
Caution: After taking such drugs, care should be taken to avoid working in a hot environment and avoid exposure to the sun.
5. Sympathomimetic drugs. Clinical representative drugs are ephedrine, monoamine oxidase inhibitors, etc.. These drugs mainly promote the release of dopamine, norepinephrine, 5-hydroxytryptamine and other neurotransmitters or prevent their reabsorption to activate the corresponding receptors, thereby constricting blood vessels, reducing skin blood flow and reducing heat dissipation; they can also increase muscle excitability and strengthen muscle contraction, resulting in increased heat production and increasing body temperature.
Caution: After taking such drugs, avoid being in a hot environment for a long time.
6. phenothiazine anti-psychotic drugs. Commonly used are chlorpromazine, endorphin, trifluoperazine, etc.. In high temperature environment, these drugs will inhibit the compensatory effect of the hypothalamus and can cause hyperthermia or even heat stroke.
Caution: After taking such drugs in summer, keep the room ventilated to lower the room temperature.