Using recombinant human interaction α 2B adverse reactions of injection


alopah Date:2021-09-15 14:48:17 From:alopah.com
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Using Recombinant Human Interferon α2b Injection The most common adverse reactions of 2B injection are flu like symptoms such as fever, chills, fatigue, headache, muscle soreness, anorexia, etc. the addition of antipyretic analgesics (paracetamol, etc.) can reduce or eliminate these symptoms, and these symptoms can also be alleviated with continued medication or dose adjustment. The common hematological abnormalities were leucopenia, thrombocytopenia and elevated transaminase.

 

Other adverse reactions of interferon a reported in the literature include diarrhea, nausea, hypertension, hypotension, vomiting, joint pain, perceptual damage, insanity, vertigo, dyskinesia, paresthesia, anxiety, depression, tension, drowsiness, hair loss, transient rash and pruritus; And rare thigh spasm, constipation, insomnia, herpetic rash, labial herpes (non herpetic), rash, urticaria, hot flashes, tachycardia, epistaxis, stomatitis, paralytic colic, coagulation diseases (prolongation of prothrombin time and partial thrombin activating enzyme time), agitation, cough, furuncle and visual abnormalities; There are also rare postural hypotension, skin erythema, thyroid dysfunction, dyspepsia, purpura, dyspnea, sneezing, injection site reaction and inflammation, eye movement paralysis, nasal congestion, gastrointestinal flatulence, increased saliva, hyperglycemia and ulcerative stomatitis.

 

contraindication

This product contains recombinant human interferon α In addition to 2B, it also contains sodium chloride, citric acid, disodium hydrogen phosphate and hydroxyethyl starch. It does not contain preservatives and blood extraction components. It is prohibited for those who have a history of allergy to any component of the preparation.

 

recombinant human interaction α 2B adverse reactions of injection

 

People with severe heart disease.

Severe abnormal liver, kidney or bone marrow function.

Epilepsy and impairment of central nervous system function.

Those who cannot tolerate this product due to other serious diseases.

 

matters needing attention

This product is colorless and transparent liquid. It shall not be used in case of abnormal phenomena such as turbidity or precipitation, damage of medicine bottle or pre filled glass syringe, expiration and failure of medicine.

 

In order to avoid possible pollution, the inner package can be opened at the front. Any opened medicine bottle or pre filled glass syringe shall be discarded after extracting the required dose of medicine or injection.

 

Medication for pregnant and lactating women 1. Pregnant women have limited medication experience, and the method of safe use of this product during pregnancy has not been established. Therefore, when pregnant women need this product very much, it should be carefully considered by clinicians. It can be used only when the benefit of the drug to the mother is greater than the potential risk to the fetus.

 

There is no data to show whether interferon is secreted by breast milk after using this product. When lactating women need medication, they should consider the importance of this product to the mother to decide whether to terminate lactation or medication.

 

Medication for children

Children’s medication experience is still limited. For such cases, we should carefully weigh the advantages and disadvantages and follow the doctor’s advice.

 

Medication for elderly patients

For elderly patients with advanced heart disease and cancer, ECG should be checked before and during the treatment period, dose adjustment should be made according to the doctor’s advice, or the use of this product should be stopped.

 

Drug interaction

Interferon may change the activity of some enzymes, especially the activity of cytochrome P450. Therefore, the metabolism of cimetidine, warfarin, theophylline, diazepam, propranolol and other drugs is affected. When combined with drugs with central effect, there will be interaction.

 

Drug overdose

There has been no report of drug overdose, but serious fatigue and weakness can occur when large doses are used.

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